GW26-e1539 Association of abnormal uric acid metabolism and atrial fibrillation in patients with essential hypertension

RESULTS Participants with elevated ALT had higher levels of almost all cardiometabolic risk factors than other participants. Among individuals with elevated ALT, the weight, height, WC, and BMI, which were indicators for general and abdominal obesity, were significantly higher than those with normal ALT. The difference was not significant for the race, current smoking or physical activity. In other cardiometabolic risk factors, such as SBP, DBP, FPG, TC, TG, LDL-C, and serum uric acid, were all strongly higher in elevated ALT group than normal ALT group. The logistic regression analysis revealed that male sex, younger age, and presence of high TC, high TG, low HDL-C, current smoking status, BMI above 25 kg/m, abdominal obesity, hyperuricemia, and HtgW phenotype were significantly associated with elevated ALT level. Sex-related differences were also discussed. For the male, hypertension (OR 1.33, 95% CI 1.08-1.62), high TC (OR 1.63, 95% CI 1.23-2.17), high TG (OR 1.62, 95% CI 1.25-2.09), BMI above 25 kg/m (OR 1.52, 95% CI 1.07-2.18), and hyperuricemia (OR 1.92, 95% CI 1.52-2.40) were statistically related to an elevated serum ALT, but this was not so for the female.